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Cellular and Molecular mechanisms underlying
the maintenance of telomere integrity.
Telomeres are special chromatin structures at chromosome ends that are essential for genomic stability, and play critical roles in aging and tumorigenesis. Our research focuses on understanding the mechanism underlying telomere maintenance, specifically on how DNA replication/repair factors maintain telomere stability, as well as understanding the diseases associated with telomere dysfunction.
Lin, W.*, Sampathi, S.*, Dai, H.*, Liu, C., Zhou, M. Hu, J., Huang, Q., Campbell, J., Zheng, L., Chai, W$., Shen, B. (2013) Mammalian DNA2 cleaves telomeric G4 to alleviate replication stress and maintain telomere integrity. Under revision. EMBO J ($co-corresponding author, *equal contribution)
Huang, C., Dai, X., and *Chai, W. (2012) Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Research. 22(12):1681-95. PMID: 22964711 (cover page article) (IF: 8.190)
Dai, X., Huang, C., and *Chai, W. (2012) CDK1 differentially regulates G-overhang generation at leading- and lagging- strand telomeres in telomerase negative cells in the G2 phase. Cell Cycle. 11 (16) 2959-3142. PMID: 22871736 (IF: 5.359)
Gu, P., Min, J., Wang, Y., Huang, C., Peng, T., Chai, W. and Chang, S. (2012) CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO Journal 31(10):2309-21. PMID: 22531781 (IF: 9.205)
Wu, X., Xu, Y., Chai, W. and Her, C. (2011) Causal link between microsatellite instability and hMRE11 dysfunction in human cancers. Molecular Cancer Research 9(11):1443-8. PMID: 21849470 (IF: 4.16)
Sampathi, S. and Chai, W. (2011). "Mapping the FEN1 interaction domain with hTERT." Biochemical and biophysical research communications 407(1): 34-38.
Sampathi, S. and Chai, W. (2011). "Telomere replication: poised but puzzling." Journal of cellular and molecular medicine 15(1): 3-13.
Dai, X., Huang, C., Bhusari, A., Sampathi, S, Schubert, K. and Chai, W. (2010) Molecular Steps of G-overhang Generation at Human Telomeres and Its Function in Chromosome End Protection. EMBO J. 29(16):2788-801.
Sampathi, S, Bhusari, A., Shen, B., Chai, W. (2009) Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. J. Biol. Chem. 284(6):3682-90.
Gardner, J.P., Kimura, M., Chai, W., Durrani, J.F., Tchakmakjian, L. Cao, X., Lu, X., Li, G., Peppas, Skurnick, T.J., Wright, W.E., Shay, J.W., Aviv, A. (2007) Telomere dynamics in macaques and humans. J. Gerontology: Biol. Sci. Med. Sci., 62(4): 367-374