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Chromosome abnormalities in pregnancy; meiotic recombination
Over 50% of all human pregnancy loss is due to chromosome imbalance in the fetus, making chromosome abnormalities the leading cause of reproductive failure. One of the primary aims of my laboratory is the use of cytogenetic and molecular techniques to study the origin and etiology of human chromosome abnormalities, with the aim being to uncover basic mechanisms responsible for the errors. Additionally, because of the importance of abnormal meiotic recombination to the genesis of human trisomies, we have recently initiated a series of studies to examine factors responsible for “setting” recombination levels in mammalian males and females.
Gabriel, A. S., T. J. Hassold, et al. (2011). "An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype data." Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19(2): 155-163.
Lawson, C., M. Gieske, et al. (2011). "Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A." Biology of reproduction 84(1): 79-86.
Billings, T., E. E. Sargent, et al. (2010). "Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping." PloS one 5(12): e15340.
Murdoch, B., N. Owen, et al. (2010). "Multiple loci contribute to genome-wide recombination levels in male mice." Mammalian genome : official journal of the International Mammalian Genome Society 21(11-12): 550-555.
Hunt, P. and T. Hassold (2010). "Female meiosis: coming unglued with age." Current biology : CB 20(17): R699-702.
Hassold, T. (2010). "ASHG Awards and Addresses. 2009 William Allan Award introduction: Huntington F. Willard." American journal of human genetics 86(3): 316-317.
Zheng, P., M. D. Griswold, et al. (2010). "Predicting meiotic pathways in human fetal oogenesis." Biol Reprod 82(3): 543-551.
Hassold, T. and P. Hunt (2009). "Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew." Current opinion in pediatrics 21(6): 703-708.
Cheng, E. Y., P. A. Hunt, et al. (2009). "Meiotic recombination in human oocytes." PLoS genetics 5(9): e1000661.
Hunt, P. A., M. Susiarjo, et al. (2009). "The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction." Biology of reproduction 81(5): 807-813.
Hassold, T., T. Hansen, P. Hunt, and C. VandeVoort, "Cytological studies of recombination in rhesus males." Cytogenet Genome Res, 2009. 124(2): p. 132-8.
Houmard, B., C. Small, L. Yang, T. Naluai-Cecchini, E. Cheng, T. Hassold, and M.Griswold, "Global gene expression in the human fetal testis and ovary." Biol Reprod, 2009. 81(2): p. 438-43.
Myers, J.P., F.S. vom Saal, B.T. Akingbemi, K. Arizono, S. Belcher, T. Colborn, I. Chahoud, D.A. Crain, F. Farabollini, L.J. Guillette, Jr., T. Hassold, S.M. Ho, P.A. Hunt, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, J.A. McLachlan, A. Nadal, J. Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B.S. Rubin, G. Schoenfelder, C. Sonnenschein, A.M. Soto, C.E. Talsness, J.A. Taylor, L.N. Vandenberg, J.G. Vandenbergh, S. Vogel, C.S. Watson, W.V. Welshons, and R.T. Zoeller, "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A." Environ Health Perspect, 2009. 117(3): p. 309-15.
Muhlhauser, A., M. Susiarjo, C. Rubio, J. Griswold, G. Gorence, T. Hassold, and P.A. Hunt, "Bisphenol A effects on the growing mouse oocyte are influenced by diet." Biol Reprod, 2009. 80(5): p. 1066-71.
Anderson, E.L., A.E. Baltus, H.L. Roepers-Gajadien, T.J. Hassold, D.G. de Rooij, A.M. van Pelt, and D.C. Page, "Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice." Proc Natl Acad Sci U S A, 2008. 105(39): p. 14976-80.
Hunt, P.A. and T.J. Hassold, "Human female meiosis: what makes a good egg go bad?" Trends Genet, 2008. 24(2): p. 86-93.
Sanderson, M.L., T.J. Hassold, and D.T. Carrell, "Proteins involved in meiotic recombination: a role in male infertility?" Syst Biol Reprod Med, 2008. 54(2): p. 57-74.
Hall, H.E., E.R. Chan, A. Collins, L. Judis, S. Shirley, U. Surti, L. Hoffner, A.E. Cockwell, P.A. Jacobs, and T.J. Hassold, "The origin of trisomy 13." Am J Med Genet A, 2007. 143A(19): p. 2242-8.
Hall, H.E., U. Surti, L. Hoffner, S. Shirley, E. Feingold, and T. Hassold, "The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction." Am J Med Genet A, 2007. 143A(19): p. 2249-55.
Hassold, T., H. Hall, and P. Hunt, "The origin of human aneuploidy: where we have been, where we are going." Hum Mol Genet, 2007. 16 Spec No. 2: p. R203-8.
Hall, H., P. Hunt, and T. Hassold, "Meiosis and sex chromosome aneuploidy: how meiotic errors cause aneuploidy; how aneuploidy causes meiotic errors." Curr Opin Genet Dev, 2006. 16(3): p. 323-9.
Topping, D., P. Brown, L. Judis, S. Schwartz, A. Seftel, A. Thomas, and T. Hassold, "Synaptic defects at meiosis I and non-obstructive azoospermia." Hum Reprod, 2006. 21(12): p. 3171-7.
Vallente, R.U., E.Y. Cheng, and T.J. Hassold, "The synaptonemal complex and meiotic recombination in humans: new approaches to old questions." Chromosoma, 2006. 115(3): p. 241-9.
Lynn A, Schrump S, Cherry J, Hassold T, Hunt P. 2005. "Sex, Not Genotype, Determines Recombination Levels in Mice." Am J Hum Genet. 77(4):670-5.
Hodges CA, Revenkova E, Jessberger R, Hassold TJ, Hunt PA. 2005. "MC1beta-deficient female mice provide evidence that cohesions are a missing link in age-related nondisjunction." Nat Genet. 37(12):1351-5.
Brown PW, Judis L, Chan ER, Schwartz S, Seftel A, Thomas A, Hassold TJ, 2005. "Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male." Am J Hum Genet. 77(4)556-66.
Lamb, N. E., Sherman, S. L., and Hassold, T. J. (2005). "Effect of meiotic recombination on the production of aneuploid gametes in humans." Cytogenet Genome Res 111, 250-5.
Mann, M. B., Hodges, C. A., Barnes, E., Vogel, H., Hassold, T. J., and Luo, G.(2005)."Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome." Hum Mol Genet 14, 813-25
Cherry SM, Hunt PA, Hassold TJ. (2004) "Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation." Mutat Res. 564(2):115-28.
Koehler KE, Millie EA, Cherry JP, Schrump SE, Hassold TJ. (2004) "Meiotic exchange and segregation in female mice heterozygous for paracentric inversions." Genetics. 166(3):1199-214.
Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ. (2003) "Bisphenol a exposure causes meiotic aneuploidy in the female mouse." Curr Biol. 13(7):546-53.
Koehler KE, Millie EA, Cherry JP, Burgoyne PS, Evans EP, Hunt PA, Hassold TJ.(2002) Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice. Genetics. 162(3):1367-79.