|Department:||Department of Biology|
|Credentials:||2009 - Ph.D., Washington State University - Biochemistry|
|Office:||Science Building 236L|
|Mailing Address:||Central Washington University|
Science Building 236L
400 University Way
Ellensburg, WA 98926
|Web Site:||Click here|
Ovarian & metabolic dysfunction in presence of excess androgens; Hormonal control of ovarian function and development
Proper regulation of hormones and steroid receptor signaling in ovarian cells is essential for normal female fertility, and aberrant regulation of these processes can lead to reduced fertility. My research is focused on understanding ovarian function and hormonal imbalances that may lead to ovarian dysfunction and infertility. My laboratory uses molecular techniques to examine gene regulation and transcriptional changes that occur downstream of estrogen receptor signaling and other hormone mediated events in ovarian cells. We also utilize a mouse model of Polycystic Ovarian Syndrome (PCOS) to examine the genetic background effects of excess androgen on ovarian and metabolic functions. Currently we are using a transgenic mouse model (NAG-1 mouse) to study metabolic differences in transgenic animals exposed to excess androgens.
Peecher D, Burns KA, Rodriguez KF, Korach KS and Binder AK. Postnatal Ovarian Transdifferentiation in the Absence of Estrogen Receptor Signaling. In preparation.
Binder AK, Kosak J, Janhardhan KS, Moser G, Eling T and Korach KS. Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation. PLoS ONE. 2016: 11(1): DOI:10.1371/journal.pone.0146518
Wardell JR, Hodgkinson KM, Binder AK, Seymour KA, Korach KS, Vanderhyden BC, and Freiman RN. Estrogen-Reponsiveness of the TFIID Subunit TAF4B in the Normal Mouse Ovary and in Ovarian Tumors. Biology of Reproduction 2013; 89(5): 116, 1-9.
Binder AK*, Rodriguez KF*, Stockton PS, Hamilton KJ, Reed CE, and Korach KS. The absence of ERβ results in altered gene expression in ovarian granulosa cells from in vivo preovulatory follicles. Endocrinology. 2013; 154(6): 2174-78.
Binder AK, Grammer JC, Herndon MK, Stanton JD and Nilson JH. GnRH Regulation of Jun and Atf3 Requires Calcium, Calcineurin, and NFAT. Molecular Endocrinology 2012; 26(5) 873-886.
Salisbury TB*, Binder AK*, Grammer JC, and Nilson JH. GnRH-Regulated Expression of Jun and JUN Target Genes in Gonadotropes Requires a Functional Interaction between TCF/LEF Family Members and β-catenin. Molecular Endocrinology 2009; 23(3): 402-411.