Hormonal control of ovarian function and development; Ovarian dysfunction in presence of excess androgen
Proper regulation of hormones and steroid receptor signaling in ovarian cells is essential for normal female fertility, and aberrant regulation of these processes can lead to reduced fertility. My research is focused on understanding ovarian function and hormonal imbalances that may lead to ovarian dysfunction and infertility. My laboratory uses molecular techniques to examine gene regulation and transcriptional changes that occur downstream of estrogen receptor signaling and other hormone mediated events in ovarian cells. We also utilize a mouse model of Polysystic Ovarian Syndrome (PCOS) to examine the genetic background effects of excess androgen on ovarian and metabolic functions.
Binder AK, Kosak J, Eling T and Korach KS. Altered reproductive function of transgenic mice overexpressing hNAG1 due to lactation deficiencies. In preparation.
Wardell JR, Hodgkinson KM, Binder AK, Seymour KA, Korach KS, Vanderhyden BC, and Freiman RN. Estrogen-Reponsiveness of the TFIID Subunit TAF4B in the Normal Mouse Ovary and in Ovarian Tumors. Biology of Reproduction2013; 89(5): 116, 1-9.
Binder AK*, Rodriguez KF*, Stockton PS, Hamilton KJ, Reed CE, and Korach KS. The absence of ERβ results in altered gene expression in ovarian granulosa cells from in vivo preovulatory follicles. Endocrinology. 2013; 154(6): 2174-78.
Binder AK, Grammer JC, Herndon MK, Stanton JD and Nilson JH. GnRH Regulation of Jun and Atf3 Requires Calcium, Calcineurin, and NFAT. Molecular Endocrinology 2012; 26(5) 873-886.
Salisbury TB*, Binder AK*, Grammer JC, and Nilson JH. GnRH-Regulated Expression of Jun and JUN Target Genes in Gonadotropes Requires a Functional Interaction between TCF/LEF Family Members and β-catenin. Molecular Endocrinology 2009; 23(3): 402-411.
Center for Reproductive Biology cited as author affiliation