Participating Faculty
Graham Young

Graham Young

Department:School of Aquatics & Fishery Sciences, UW
Credentials:1980 - Ph.D., University of Sheffield; Zoology
Phone:206-543-4291
Fax:206-685-4674
Mailing Address:School of Aquatic and Fishery Sciences
Executive Director, Western Regional Aquaculture Center
PO Box 355020
Seattle, WA 98195-5020
E-mail:grahamy@u.washington.edu


Research Interests

Fish Reproduction & Endocrinology

Research Summary

My research interests are in the endocrine regulation of development and reproduction in teleost fish. My lab’s general focus has been on the regulation of steroid production and on the role of steroid hormones in regulating processes such as metamorphosis, the stress response and gonad development. The current work of the lab is directed towards determining the mechanisms that regulate early oogenesis (oogonial proliferation, meiosis onset and primary growth). We are also studying the effects of contaminants on reproduction in fish, focusing on chemicals of emerging concern, and are developing an in vitro methods for high throughput screening of potential endocrine disrupting contaminants.

Research Publications

Baker M.R., Swanson, P. and Young, G. Injuries from non-retention in gillnet fisheries suppress reproductive maturation in escaped fish. PLoS One, 8:e69615 (2013).

Harding, L.A., Schultz, I.R., Goetz, G.W., Luckengbach, J.A., Young, G., Goetz, F.W., Swanson, P. High-throughput sequencing and pathway analysis reveal alteration of the pituitary transcriptome by 17α-ethynylestradiol (EE2) in female coho salmon, Oncorhychus kisutch. Aquatic toxicology 142-143:146-163 (2013).

Forsgren, K.L. and Young, G. 2012. Stage-specific effects of androgens and estradiol-17β on the development of late primary and early secondary ovarian follicles of coho salmon (Oncorhynchus kisutch) in vitro. Biology of Reproduction 87:1-14.

Shibata, Y., Iwamatusue, T., Suzuki, N., Young, G., Naruse, Ke., Nagahama, Y. and Yoshikuni, M. 2012. An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in madaka (Oryzias latipes). Developmental Biology 372:239-248.

Beaudreau, A.H., Andrews, K.S., Larsen, D.A., Young, G. and Bechman, B. 2011. Variation in plasma levels of insulin-like growth factor-I (IGF-I) in lingcod: relationships among season, size, and gonadal steroids. Marine Biology 158:439-450.

Miura, C., Shimizu, Y., Uehara, M., Ozaki, Y., Young, G., Miura, T. 2011. Gh is produced by the testis of Japanese eel and stimulates proliferation of spermatogonia. Reproduction 142:869-877.

Yamamoto, Y., Luckenback, A.J., Goetz, F.W., Young, G., and Swanson, P. 2011. Disruption of the salmon reproductive endocrine axis through prolonged nutritional stress: changes in circulating hormone levels and transcripts for ovarian genes involved in steroidogenesis and apoptosis. General and Comparative Endocrinology. 172:331-343.

Lubzens, E., Young, G., Bobe, J and Cerda, J. 2010. Oogenesis in teleosts: how eggs are formed. General and Comparative Endocrinology. 165:367-389.

Nakamura, I., M. Kusakabe, and Young, G. 2009. Differential suppressive effects of low physiological doses of estradiol-17β in vivo on levels of mRNAs encoding steroidogenic acute regulatory protein and three steroidogenic enzymes in previtellogenic ovarian follicles of rainbow follicles of rainbow trout. General and Comparative Endocrinology. 163:318-323.

Kusakabe, M., M.D. Zuccarelli, I. Nakamura, and Young, G. 2009. Steroidogenic acute regulatory protein in white sturgeon (Acipenser transmontanus): cDNA cloning, sites of expression and transcript abundance in corticosteroidogenic tissue after an acute stressor. General and Comparative Endocrinology. 162:233-240.

Washington State University