|Department:||Department of Integrative Physiology and Neuroscience|
|Credentials:||2007 - Ph.D. Columbia University; Psychology|
Department of Integrative Physiology and Neuroscience
Behavioral Neuroscience, Circadian Rhythms, Stress, Metabolism/Obesity, Neuroendocrinology, Depression/Anxiety, Cognition, Ageing/Development, Neuropeptides, Sex Differences
Circadian (daily) rhythms are evolutionarily ancient, present in almost all organisms, and regulate nearly every biological process. In our modern industrialized society, we have altered the relationship between our circadian rhythms and the day-night cycle. In many cases we are active long into the night and sleep during the day. In extreme cases, such as shift-workers and trans-meridian air travelers (e.g. jet-lag), overriding circadian rhythms can be more than just a nuisance. Chronically, this can lead to heath problems, including development of the metabolic syndrome, increased risk of heart disease, higher incidences of certain types of cancer, disrupted immune responses, and increased risk of suffering from a major depressive syndrome. Dr. Karatsoreos' current research focuses on the relationship between circadian rhythms and mental and physical health, highlighting how circadian rhythms modulate physiology and behavior, as well as how disrupting them in animal models can produce physiological and behavioral abnormalities that change an animal’s susceptibility to further environmental or psychological stress. The Karatsoreos Lab also focuses on the effect of gonadal hormones on circadian timing, exploring how androgens can alter the structure and function of the brain clock in the hypothalamic suprachiasmatic nucleus, and the behavioral ramifications of these changes. It is hoped these models will provide an understanding of how dysregulation of the body’s timing systems interact to produce changes in behavior and physiology, and will potentially lead to new clinical interventions to alleviate some of the physical and mental health consequences of our modern lifestyles.
Karatsoreos, I.N. and McEwen, B.S. (2011) “Psychobiological Allostasis: Resistance, Resilience and Vulnerability.” Trends in Cognitive Science. 15(12): 576-584.
Karatsoreos, I.N., Bhagat, S.M., Bloss, E.B., Morrison, J.H., McEwen, B.S. (2011) “Disruption of circadian clocks has ramifications for metabolism, brain and behavior.” PNAS 108(4):1657-62. **Featured in Faculty of 1000.
Karatsoreos, I.N., Butler, M.P., LeSauter, J., Silver, R. (2011) “Androgen regulation of plasticity in the suprachiasmatic nucleus brain clock.” Endocrinology 152: 1970-1978.
Karatsoreos, I.N., Bhagat, S., Bowles, N.P., Weil, Z.M., Pfaff, D.W., McEwen, B.S. (2010) “Endocrine and physiological changes in response to chronic corticosterone: A potential model of the metabolic syndrome in mouse”. Endocrinology. 151: 2117-2127. **Featured in Faculty of 1000.
Karatsoreos, I.N. and Silver, R. (2007) “The neuroendocrinology of the suprachiasmatic nucleus as a conductor of circadian time in mammals” Endocrinology. Dec; 148 (12):5640-7
Karatsoreos I.N., Wang, A., Sasanian, J., Silver, R. (2007). “A Role for Androgens in Regulating Circadian Behavior and the Suprachiasmatic Nucleus.” Endocrinology. Nov; 148(11):5487-95.