|Department:||School of Molecular Biosciences, WSU|
|Credentials:||1996 - Ph.D., Cornell University|
|Office:||Biotechnology Life Sciences 433|
School of Molecular Biosciences
The role of lipids in reproduction and development.
My research program aims to gain insight into the mechanisms through which the physical properties and regulatory actions of specific lipids impact the cell biology and physiology of animals. The implications of this research extend from understanding how specific fatty acids affect cell signaling to dissecting the fat regulatory pathways involved in obesity and related diseases. WE use the nematode model Caenorhabditis elegans and a combination of genetic, genomic and biochemical approaches to understand the regulation, function and biosynthesis of unsaturated fatty acids.
Unsaturated fatty acids play vital roles as structural components of membranes and as signaling molecules. We have isolated C. elegans mutants with altered capacity to synthesis unsaturated fatty acids. These mutants provide new tools to understand the roles unsaturated fatty acids in membrane biology and cell function. We discovered that dietary supplementation with an omega-6 long-chain polyunsaturated fatty acid, DGLA (20:3n-6), causes defects in the development and maintenance of germ cells. Nematodes feeding on DGLA, but not other long-chain polyunsaturated fatty acids become sterile, partly due to excess apoptosis of germ cells. Our molecular, genetic, and biochemical studies promise to shed light on the roles of polyunsaturated fatty acids in reproductive processes.
Shi, X., Li, J, Zou, X, Greggain, J., Rodkaer, S.V., Faergeman, N.J., Liang, B., and Watts, J.L. (2013) “Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.” Journal of Lipid Research 54(9):2504-14.
Vrablik, T.L. and Watts, J.L. (2013) “Polyunsaturated Fatty Acid Derived Signaling in Reproduction and Development: Insights from C. elegans and Drosophila”. Molecular Reproduction and Development 80(4):14-25.
Webster, C.M., Deline, M., and Watts, J.L. (2013), “Stress response pathways confer protection from omega-6 polyunsaturated fatty acid-mediated destruction of germ cells in C. elegans”, Developmental Biology 373(1):14-25.
Vrablik, T.L. and Watts, J.L. (2012) Emerging Roles for Specific Fatty Acids in Developmental Processes”. Genes and Development 26(7) 631-7.
Walker, A.K., Jacobs, R.L., Watts, J.L., Rottiers, V., Jiang, K., Fionnegan, D.M., Shioda, T., Hnasen, M., Yang, F., Niebergall, L.J., Vance, D.E., Tzoneva, M., Hart, A.C., and Naar, A.M. (2011) “A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans: Cell 147(4):840-852.
Walker, A.K., F. Yang, et al. (2010). “Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.” Genes & Development 24(13):1403-1417.