Participating Faculty

Jonathan Andy Schidt

Jonathan "Andy" Schmidt

Department:Department of Biology
Credentials:2005 - Washington State University-Animal Sciences
Mailing Address:Department of Biology
Spokane Community College
Spokane, WA 99217

Research Interests

Quantitative biology and genomics of male germ cell development

Research Summary

My research interests focus on the biology of the mammalian spermatogonial stem cell with particular emphasis on regulators of stem cell fate decisions and the development of techniques for the isolation, culture and long-term preservation of these cells.  

Research Publications

Kim KJ, Lee YA, Kim BJ, Kim YH, Jung MS, Ha SJ, Kang HG, Kim BG, Choi SH, Hwang S, Schmidt JA, Ryu BY.  Cryopreservation of putative pre-pubertal bovine spermatogonial stem cells by slow-freezing.  Cryobiology.  2015; 70:175-83.

Lee YA, Kim YH, Ha SJ, Kim KJ, Kim BJ, Choi SH, Kim IC, Schmidt JA, Ryu BY.  Cryopreservation of porcine spermatogonial stem cells by slow-freezing in trehalose.  J Anim Sci.  201; 92:984-995.

Kim KJ,  Cho CM, Kim BG, Lee YA, Kim BJ, Kim YH, Kim CG, Schmidt JA, Lee SH, Ryu BY.  Lentiviral modification of enriched populations of bovine gonocytes.  J Anim Sci.  2013; 92:106-18 

Kim YH, Kim BJ, Kim BG, Lee YA, Kim KJ, Hwang SS, Chung HJ, Woo JS, Park JK, Schmidt JA, Pang, MG, Ryu BY. Stage-specific embryonic antigen-1 expression by undifferentiated spermatogonia in the pre-pubertal boar testis.  J Anim Sci 2013; 91:3143-54. 

Lee YA, Kim YH, Kim BJ, Kim BG, Kim KJ, Auh JH, Schmidt JA, Ryu BY.  Cryopreservation in trehalose preserves functional capacity of murine spermatogonial stem cells.  PLoS One 2013; 8:e54889. 

Schmidt JA, Abramowitz LK, Kubota H, Wu X, Niu Z, Avarbock MR, Tobias JW, Bartolomei MS, Brinster RL.  In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function.  Biol Reprod 2011; 84:698-706.

Wu X, Schmidt JA, Avarbock MR, Tobias JW, Carlson CA, Kolon TF, Ginsberg JP, Brinster RL.  Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules.  Proc Natl Acad Sci U S A. 2009; 106:21672-21677.

Schmidt JA, Brinster RL.  Spermatogonial Stem Cell Transplantation.  In: Hermann B, Orwig K (eds), Male Germline Stem Cells: Developmental and Regenerative Potential.  Springer/Humana Press 2011. 

Kubota H, Avarbock MR, Schmidt JA, Brinster RL.  Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny.  Biol Reprod. 2009; 81:293-301.   

Schmidt JA, Avarbock M, Tobias JW, Brinster RL.  Identification of GDNF-regulated genes important for spermatogonial stem cell self-renewal in the rat.  Biol Reprod. 2009; 81:56-66.  

Schmidt JA, Oatley JM, Brinster RL.  Female mice delay reproductive aging in males.  Biol Reprod 2009; 80:1009-14.

Editors choice comment: Postponing Senescence; Science 2009; 323:854 

Caires KC, Schmidt JA, Oliver AP, de Avila JM, McLean DJ.  Endocrine regulation of the establishment of spermatogenesis in pigs.  Reprod. Domest. Anim.  2008; 43(Suppl 2):280-7.

Washington State University