Participating Faculty
Jonathan Schmidt

Jonathan "Andy" Schmidt

Department:Department of Biology
Credentials:2005~Washington State University-Animal Sciences
Mailing Address:Department of Biology
Spokane Community College
Spokane, WA 99217

Research Interests

Quantitative biology and genomics of male germ cell development

Research Summary

My research interests focus on the biology of the mammalian spermatogonial stem cell with particular emphasis on regulators of stem cell fate decisions and the development of techniques for the isolation, culture and long-term preservation of these cells.

Research Publications

Selected Publications 2008-2013

Kim Y-H, Kim B-J, Kim B-G, Lee Y-A, Kim K-J, Hwang S-S, Chung H-J, Woo J-S, Park J-K, Schmidt JA, Pang, M-G, Ryu B-Y. Stage-specific embryonic antigen-1 expression by undifferentiated spermatogonia and spermatogonial stem cells in the pre-pubertal boar testis. 2013; in review.

Lee Y-A, Kim Y-H, Kim B-J, Kim B-G, Kim K-J, Auh J-H, Schmidt JA, Ryu BY. Cryopreservation inTrehalose Preserves Functional Capacity of Murine Spermatogonial Stem Cells. PLOS One 2013; 8:e54889

Schmidt JA, Abramowitz LK, Kubota H, Wu X, Niu Z, Avarbock MR, Tobias JW, Bartolomei MS, Brinster RL. In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function. Biol Reprod 2011; 84:698-706.

Wu X, Schmidt JA, Avarbock MR, Tobias JW, Carlson CA, Kolon TF, Ginsberg JP, Brinster RL. Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules. Proc Natl Acad Sci U S A. 2009; 106:21672-21677.

Schmidt JA, Brinster RL. Spermatogonial Stem Cell Transplantation. In: Hermann B, Orwig K (eds), Male Germline Stem Cells: Developmental and Regenerative Potential. Springer/Humana Press 2011.

Kubota H, Avarbock MR, Schmidt JA, Brinster RL. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny. Biol Reprod. 2009; 81:293-301.

Schmidt JA, Avarbock M, Tobias JW, Brinster RL. Identification of GDNF-regulated genes important for spermatogonial stem cell self-renewal in the rat. Biol Reprod. 2009; 81:56-66.

Schmidt JA, Oatley JM, Brinster RL. Female mice delay reproductive aging in males. Biol Reprod 2009; 80:1009-14. Editors choice comment: Postponing Senescence; Science 2009; 323:854

Caires KC, Schmidt JA, Oliver AP, de Avila JM, McLean DJ. Endocrine regulation of the establishment of spermatogenesis in pigs. Reprod. Domest. Anim. 2008; 43(Suppl 2):280-7.

Washington State University