Participating Faculty
Mark McGuire

Mark McGuire

Department:Animal and Veterinary Sciences, UI
Credentials:1994~Ph.D., Cornell University
Office:Ag Biotech 307
Mailing Address:Ag Biotech 307
University of Idaho
Moscow, ID 83844-2330

Research Interests

Mammary Physiology, Nutrition, Microbiome, Mastitis

Research Summary

Milk is a complex mixture of nutrients. Alterations in milk composition may enhance nutritional properties of bovine milk for the human consumer and may reduce the risk of mastitis for the cow. Our studies have described nutritional and metabolic means to enrich milk with conjugated linoleic acid (CLA) and omega-3 fatty acids in both cows and women. Milk lipids, particularly fatty acids, could be involved in protection against pathogens that cause mastitis. Certain fatty acids in milk are bacteristatic or bactericidal toward a major mastitis pathogen, Staphylococcus aureus. Milk lipids respond to an infection in ways suggesting they are active components protecting cows from pathogens. Staphylococcus aureus has methods to protect against these changes in milk lipids that might relate to this bacterium’s virulence. Mastitis is also a disease of lactating women, who too commonly contract mastitis due to the same organism. Efforts to reduce the risk of mastitis in women would lead to improvements in breast-feeding, a clear choice for the human infant. Milk may also be an important source of healthy bacteria for the nursing infant. Milk from healthy women contains many types of bacteria as determined through pyrosequencing. The importance of the milk microbiome on development of the infant gut and health of the breast are areas under study.

Research Publications

Selected 2005-2011

Ahmadzadeh, A., F. Frago, B. Shafii, J.C. Dalton, W.J. Price, and M.A. McGuire, "Effect of clinical mastitis and other diseases on reproductive performance of Holstein cows." Anim Reprod Sci, 2009. 112(3-4): p. 273-82.

Seo, K.S., J.Y. Park, W.C. Davis, L.K. Fox, M.A. McGuire, Y.H. Park, and G.A. Bohach, "Superantigen-mediated differentiation of bovine monocytes into dendritic cells." J Leukoc Biol, 2009. 85(4): p. 606-16.

Theurer, M.L., E. Block, W.K. Sanchez, and M.A. McGuire, "Calcium salts of polyunsaturated fatty acids deliver more essential fatty acids to the lactating dairy cow." J Dairy Sci, 2009. 92(5): p. 2051-6.

Annen, E. L., A. C. Fitzgerald, P. C. Gentry, M. A. McGuire, A. V. Capuco, L. H. Baumgard and R. J. Collier (2007). "Effect of continuous milking and bovine somatotropin supplementation on mammary epithelial cell turnover." J Dairy Sci 90(1): 165-83.

Mosley, E.E. and M.A. McGuire, "Methodology for the in vivo measurement of the delta9-desaturation of myristic, palmitic, and stearic acids in lactating dairy cattle." Lipids, 2007. 42(10): p. 939-45.

Mosley, S.A., E.E. Mosley, B. Hatch, J.I. Szasz, A. Corato, N. Zacharias, D. Howes, and M.A. McGuire, "Effect of varying levels of fatty acids from palm oil on feed intake and milk production in Holstein cows." J Dairy Sci, 2007. 90(2): p. 987-93.

Mosley, S.A., A.M. Shahin, J. Williams, M.A. McGuire, and M.K. McGuire, "Supplemental conjugated linoleic acid consumption does not influence milk macronutrient contents in all healthy lactating women." Lipids, 2007. 42(8): p. 723-9.

Kelsey, J.A., K.W. Bayles, B. Shafii, and M.A. McGuire, "Fatty acids and monoacylglycerols inhibit growth of Staphylococcus aureus." Lipids, 2006. 41(10): p. 951-61.

Mosley, E.E., A. Nudda, A. Corato, E. Rossi, T. Jenkins, and M.A. McGuire, "Differential biohydrogenation and isomerization of [U-(13)C]oleic and [1-(13)C]oleic acids by mixed ruminal microbes." Lipids, 2006. 41(5): p. 513-7.

Mosley, E.E., B. Shafii Dagger, P.J. Moate, and M.A. McGuire, "cis-9, trans-11 conjugated linoleic acid is synthesized directly from vaccenic acid in lactating dairy cattle." J Nutr, 2006. 136(3): p. 570-5.

Hristov, A.N., L.R. Kennington, M.A. McGuire, and C.W. Hunt, "Effect of diets containing linoleic acid- or oleic acid-rich oils on ruminal fermentation and nutrient digestibility, and performance and fatty acid composition of adipose and muscle tissues of finishing cattle". J Anim Sci, 2005. 83(6): p. 1312-21.

Mosley, E.E., A.L. Wright, M.K. McGuire, and M.A. McGuire, "trans Fatty acids in milk produced by women in the United States." Am J Clin Nutr, 2005. 82(6): p. 1292-7.

Washington State University