Participating Faculty

Michelle 'Shelley' McGuire

Michelle 'Shelley' McGuire

Department:School of Biological Sciences, WSU
Office:Eastlick 375
Mailing Address:Washington State University
School of Biological Sciences
PO Box 644236
Pullman, WA 99164-4236

Research Interests

Mammary Physiology

Research Summary

Although breastfeeding is considered the optimal form of infant feeding, the regulation of milk constituents is not fully understood. A more comprehensive understanding of the variability and regulation of milk composition in humans is important both for scientific and public health purposes. Furthermore, it is known that lactation is beneficial for the postpartum woman. For example, lactation results in a period of infertility and a decreased risk for certain forms of breast cancer. Thus, we have been interested in studying the influence of lactation and breastfeeding on both maternal and infant health. Specifically, our research has focussed recently on the investigation of maternal fatty acid intake on milk composition (and thus, infant nutrition) as well as risk of breast cancer in the mother. Of particular interest to us is a group of fatty acids called the "conjugated linoleic acids (CLA)," which have been shown to influence breast cancer risk in animal models as well as growth and nutrient partitioning in the growing animal. Studies in lactating women show clearly that maternal CLA intake influences milk CLA content. Further, we have shown that supplementation with commercially-available CLA can quickly and significantly decrease milk fat content. Currently, we are continuing this research by helping to elucidate which CLA isomer is responsible for these effects on milk composition as well as studying the potential interaction between lactation and CLA intake on risk of mammary cancer. Our studies utilize both human subjects and animal models and are intended to add to our understanding of the regulation of milk composition as well as the health implications of variations in maternal and infant nutrition and behaviors during the postnatal period.

Research Publications

Selected 2005-2011

Picciano MF, Yetley EA, Coates PM, & McGuire MK. (2009) "Update on folate and human health." (invited review) Nutrition Today. 44:142-152.

Picciano MF, McGuire MK. (2009) "Use of dietary supplements by pregnant and lactating women in North America." Am J Clin Nutr; 89:663S-7S.

Ryan-Borchers T, Park JS, Chew BP, Beerman KA & McGuire MK. (2008) "Soy isoflavones modulate do not influence thyroid function in healthy postmenopausal women." Topics Clin Nutr 23:13-22.

Hasin A, Griinari M., Shahin AM, Williams J, McGuire MA & McGuire MK. (2007) "Consumption of c9,t11-18:2 or t10,c12-18:2 enriched dietary supplements does not influence milk macronutrients in healthy, lactating women." Lipids 42:835-43.

Mosley SA, Shahin AM, Williams JE, McGuire MA, & McGuire MK. (2007) "Supplemental conjugated linoleic acid (CLA) consumption does not influence milk macronutrient contents in all healthy lactating women." Lipids 42:723-729.

Fournier LR, Ryan-Borchers TA, Robison LM, Weidiger M, Park J-S, Chew BP, McGuire MK, Sclar DA, Skaer TL, & Beerman KA. (2007) "The effects of soy milk and soy isoflavone supplements on cognitive performance in healthy, postmenopausal women." J Nutr, Health, Aging 11:155-64.

Ryan-Borchers TA, Park JS, Chew BP, McGuire MK, Fournier LR & Beerman KA. (2006) "Soy isoflavones modulate immune function in healthy postmenopausal women." Am J Clin Nutr 83:1118-25.

Mosley EE, McGuire MK, Williams JE & McGuire MA. (2006) "Cis-9, trans-11 conjugated linoleic acid is synthesized from vaccenic acid in lactating women." J Nutr 136:2297-301, 2006.

Shahin AM, McGuire MK, Anderson N, Williams J. & McGuire MA. (2006) "Effects of margarine and butter consumption on distribution of trans-18:1 fatty acid isomers and conjugated linoleic acid in major serum lipid classes in lactating women." Lipids 41:141-47.

Mosley EE, Wright A, McGuire MK & McGuire MA. (2005) "Trans fatty acid concentration of milk produced by women in the United States." Am J Clin Nutr 82:1292-1297.

Anderson NK, Beerman KA, McGuire MA, Dasgupta N, Griinari MJ, Williams J & McGuire MK. (2005) "Type of dietary fat influences total milk fat content in lean women" J Nutr 135:416-421.

Ritzenthaler KL, McGuire MK, McGuire MA, Shultz TD, Koepp AE, Leudecke LO, Hanson, TW, Chew BP & Dasgupta N. (2005) "Consumption of conjugated linoleic acid (CLA) from CLA-enriched cheese does not alter milk fat or immunity in lactating women." J Nutr 135:422-430.

Washington State University