|Department:||Biological Sciences, UI|
|Credentials:||2003 - Ph.D., Iowa State University- Molecular, Cellular and Developmental Biology|
|Office:||239 Gibb Hall|
|Web Site:||Click here|
The primary goal of my research is to understand how molecular recognition cues facilitate patterning. Research will focus on discovering the mechanisms by which two recognition cues; the Down Syndrome Cell Adhesion Molecule (Dscam) and its homologue Dscam-like1 (Dscaml1), mediate development of the nervous system. Both Dscam and Dscaml1 are required for neurite lamination, neurite arborization and regulation of cell number. Therefore, understanding the mechanism by which these molecules function will advance scientific understanding of neural development on multiple fronts. Furthermore, decreasing Dscam dosage decreases the incidence of developmental cell death suggesting that the mouse may provide an excellent system in which to model enhanced developmental cell death of neurons that occurs in Down syndrome patients, who overexpress Dscam as a result of Chromosome 21 trisomy.
Schramm, R. D., Li, S., Harris, B. S., Rounds, R. P., Burgess, R. W., Ytreberg, M. F. and Fuerst, P. G., 2012. A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. In Press PLoS One (Accepted November 19, 2012).
Fuerst, P. G., Bruce, F., Rounds, R.P., Erskine, L., Burgess, R.W., 2012. Cell autonomy of DSCAM function in retinal development. Developmental Biology 361, 326-337.
Blank, M., P. G. Fuerst, et al. (2011). "The Down Syndrome Critical Region Regulates Retinogeniculate Refinement." The Journal of neuroscience : the official journal of the Society for Neuroscience 31(15): 5764-5776.
Burgess, R. W. and P. G. Fuerst (2010). "Distinct expression patterns of mitochondrially localized YFP in neuronal subsets in the retina of three transgenic mouse lines." BMC research notes 3: 253.
Fuerst, P. G., B. S. Harris, et al. (2010). "A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability." Genesis 48(10): 578-584.
Fuerst, P.G. , Bruce, F., Tian, M., Wei, W., Elstrott, J., Feller, M.B., Erskine, L., Singer, J.H., and Burgess, R.W. (2009). DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina. Neuron 2009, In Press.
Fuerst, P. G. , and Burgess R. W. Adhesion molecules in establishing retinal circuitry. Current Opinions in Neurobiology 2009, 19:1-6.
Fuerst, P.G. , Koizumi, A., Masland, R.H., and Burgess, R.W. (2008). Neurite arborization and mosaic spacing in the mouse retina require DSCAM. Nature 451, 470-474.
Brady, T.L., Fuerst, P.G. , Dick, R.A., Schmidt, C., and Voytas, D.F. (2008). Retrotransposon target site selection by imitation of a cellular protein. Molecular and Cellular Biology 28, 1230-1239.
Fuerst, P.G. , Rauch, S.M., and Burgess, R.W. (2007). Defects in eye development in transgenic mice overexpressing the heparan sulfate proteoglycan agrin. Developmental Biology 303, 165-180.