|Department:||Biological Sciences, UI|
|Credentials:||2003 - Ph.D., Iowa State University- Molecular, Cellular and Developmental Biology|
|Office:||Life Sciences South 141|
|Mailing Address:||Biological Sciences|
875 Perimeter Dr. MS3051
Moscow, ID 83844-3051
|Web Site:||Click here|
The primary goal of my research is to understand how molecular recognition cues facilitate patterning. Research will focus on discovering the mechanisms by which two recognition cues; the Down Syndrome Cell Adhesion Molecule (Dscam) and its homologue Dscam-like1 (Dscaml1), mediate development of the nervous system. Both Dscam and Dscaml1 are required for neurite lamination, neurite arborization and regulation of cell number. Therefore, understanding the mechanism by which these molecules function will advance scientific understanding of neural development on multiple fronts. Furthermore, decreasing Dscam dosage decreases the incidence of developmental cell death suggesting that the mouse may provide an excellent system in which to model enhanced developmental cell death of neurons that occurs in Down syndrome patients, who overexpress Dscam as a result of Chromosome 21 trisomy.
Simmons A.B., Bloomsburg S.J., Sukeena J.M., Miller C.J., Ortega-Burgos Y., Borghuis B.G., Fuerst P.G. (2017) DSCAM-mediated control of dendritic and axonal arbor outgrowth enforces tiling and inhibits synaptic plasticity. Proceedings of the National Academy of Sciences USA.Bruce, F.M., Brown, S., Smith, J.N., Fuerst, P.G.* and Erskine, L. (2017). DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proceedings of the National Academy of Sciences USA: Feb 14;114(7):1702-1707.
Sukeena, J.M., Galicia, C.A., Wilson, J.D., McGinn, T., Boughman, J.W., Robison, B.D., Postlethwait, J.H., Braasch, I., Stenkamp, D.L., Fuerst, P.G. (2016). Characterization and Evolution of the Spotted Gar Retina. J Exp Zool B: Nov;326(7):403-421.
Garrett, A.M., Tadenev, A.L., Hammond, Y.T., Fuerst, P.G., Burgess, R.W. (2016). Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations. Elife: Sep 16;5.
Simmons AB, Bloomsburg SJ, Billingslea SA, Merrill MM, Li S, Thomas MW, Fuerst PG. (2016). Pou4f2 knock-in Cre mouse: A multifaceted genetic tool for vision researchers. Molecular Vision: Jun 23;22:705-17.
Simmons, A.B., Merrill, M.M., Reed, J.C., Deans, M.R., Edwards, M.M. and Fuerst, P.G. (2016). Neuron lamination is required for normal development of the retinal vasculature. IOVS: Apr;57(4):1563-77.
Li, S., Mitchell, J. Briggs, D.J., Young, J.K., Long, S.S. and Fuerst, P.G. (2016). Morphological diversity of the rod spherule: A study of serially reconstructed electron micrographs. PLoS One: 11(3): e0150024.
Li, S., Woodfin, M., Long, S.S. and Fuerst, P.G. (2016). IPLaminator: an ImageJ plugin for automated binning and quantification of retinal lamination. BMC Bioinformatics: 17, 36.
Fernandes, K.A., Schramm, R. D., Li, S. Nguyen, D. Libby, R.T. and Fuerst, P.G. (2016). Postnatal RGC stress and axon remodeling in the Dscam mutant retina. Molecular and Cellular Neuroscience: 71, 1-12.
Li, S., Sukeena, J.M., Simmons, A.B., Hansen, E.J., Nuhn, R.E., Samuels, I.S. and Fuerst, P.G. (2015). DSCAM restricts neurite lamination in the mouse inner retina. Journal of Neuroscience: 35, 5640-5654.
Firl, A., Ke, J., Zhang, L., Fuerst, P.G., Singer, J. and Feller, M. (2015). Elucidating the role of AII amacrine cells in glutamatergic retinal waves. Journal of Neuroscience: 35, 1675-1686.
Andrade, G.B., Kunzelman, L., Merrill, M.M. and Fuerst, P.G. (2014). Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. Molecular Vision: 20, 1422-1433.
Nuhn, J.S. and Fuerst, P.G. (2014). Developmental localization of adhesion and scaffolding proteins at the cone synapse. Gene Expression Patterns: 16, 36-50.
Andrade, G.B., Long, S.S., Fleming, H., Li, W. and Fuerst, P.G. (2014). DSCAM localization and function at the mouse cone synapse. Journal of Comparative Neurology: 522, 2609-2633.
Keeley, P. W., et al. (2012). "Neuronal clustering and fasciculation phenotype in Dscam- and Bax-deficient mouse retinas." J Comp Neurol 520(7): 1349-1364.
Schramm, R. D., et al. (2012). "A novel mouse Dscam mutation inhibits localization and shedding of DSCAM." PLoS One 7(12): e52652.
Fuerst, P. G., Bruce, F., Rounds, R.P., Erskine, L., Burgess, R.W., 2012. Cell autonomy of DSCAM function in retinal development. Developmental Biology 361, 326-337.
Blank, M., P. G. Fuerst, et al. (2011). "The Down Syndrome Critical Region Regulates Retinogeniculate Refinement." The Journal of neuroscience : the official journal of the Society for Neuroscience 31(15): 5764-5776.
Burgess, R. W. and P. G. Fuerst (2010). "Distinct expression patterns of mitochondrially localized YFP in neuronal subsets in the retina of three transgenic mouse lines." BMC research notes 3: 253.
Fuerst, P. G., B. S. Harris, et al. (2010). "A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability." Genesis 48(10): 578-584.
Fuerst, P.G. , Bruce, F., Tian, M., Wei, W., Elstrott, J., Feller, M.B., Erskine, L., Singer, J.H., and Burgess, R.W. (2009). DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina. Neuron 2009, In Press.
Fuerst, P. G. , and Burgess R. W. Adhesion molecules in establishing retinal circuitry. Current Opinions in Neurobiology 2009, 19:1-6.
Fuerst, P.G. , Koizumi, A., Masland, R.H., and Burgess, R.W. (2008). Neurite arborization and mosaic spacing in the mouse retina require DSCAM. Nature 451, 470-474.
Brady, T.L., Fuerst, P.G. , Dick, R.A., Schmidt, C., and Voytas, D.F. (2008). Retrotransposon target site selection by imitation of a cellular protein. Molecular and Cellular Biology 28, 1230-1239.
Fuerst, P.G. , Rauch, S.M., and Burgess, R.W. (2007). Defects in eye development in transgenic mice overexpressing the heparan sulfate proteoglycan agrin. Developmental Biology 303, 165-180.