Wipawee "Joy" Winuthayanon
Roles of steroid hormones in embryo development and embryo transport.
Research SummaryMy research is focusing on understanding how hormones affect the Fallopian tube function of transporting embryos to the uterus during early pregnancy. Fallopian tube dysfunction causes infertility and ectopic pregnancy in millions of reproductive age couples worldwide. The study will provide basic reproductive biology in women during early pregnancy.
Winuthayanon W, Hewitt SC, and Korach KS. Expression of estrogen receptor α in adjacent uterine cells is crucial for cell proliferation and establishing successful pregnancy (in preparation)Winuthayanon W, Hewitt SC, Lydon JP, DeMayo FJ, and Korach KS. Selective loss of ERα in female reproductive tract causes infertility and loss of estrogen induced uterine responses. Biology of Reproduction. 87. 334-334. 10.1093/biolreprod/87.s1.334.
Winuthayanon W, Hewitt SC, and Korach KS. (2014) Uterine epithelial cell estrogen receptor α –dependent and –independent genomic profiles that underlie estrogen response. Biol Reprod. 95:110, 1-10. **NIEHS paper of the month, 02/15
Winuthayanon W, Padilla-Banks E, Myers PH, Bernhardt ML, Edin ML, Lih F, Korach KS, and Williams CJ. Oviductal estrogen receptor α signaling prevents protease-mediated embryo death. (In revision for Developmental Cell)
Binder, A. K., et al. (2015). Chapter 25 - Steroid Receptors in the Uterus and Ovary. Knobil and Neill's Physiology of Reproduction (Fourth Edition). San Diego, Academic Press: 1099-1193.
Hewitt, S. C., et al. (2015). "Development of Phenotypic and Transcriptional Biomarkers to Evaluate Relative Activity of Potentially Estrogenic Chemicals in Ovariectomized Mice." Environmental Health Perspectives 123(4): 344-352.
Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS. (2014) Novel DNA Motif Binding Activity Observed In Vivo With an Estrogen Receptor α Mutant Mouse. Mol Endo. 28: 899-911.
Winuthayanon W, Piyachaturawat P, Suksamrarn A, Arao Y, Burns KA, Hewitt SC, Pedersen LC, andKorach KS. (2013) Natural Estrogenic Compound Diarylheptanoid (D3): In vitro Mechanisms of Action and In Vivo Uterine Responses via Estrogen Receptorα. Environ Health Perspect. 121:433-9.
**NIEHS paper of the month, 06/13