Participating Faculty
WinutW09_5067d
Name:Wipawee "Joy" Winuthayanon
Department:School of Molecular Biosciences
Office:Biotechnology Life Sciences 239
Phone:509-335-8296
Fax:
Mailing Address:

School of Molecular Biosciences
Center for Reproductive Biology 
PO Box 647520
Pullman, WA 99164-7520

E-mail: winuthayanonw@vetmed.wsu.edu



Research Interests

Hormones and embryo transport

Research Summary

My research is focusing on understanding how hormones affect the Fallopian tube function of transporting embryos to the uterus during early pregnancy. Fallopian tube dysfunction causes infertility and ectopic pregnancy in millions of reproductive age couples worldwide. The study will provide basic reproductive biology in women during early pregnancy.

Research Publications

Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih F, Korach KS, and Williams CJ. (2015) Oviductal estrogen receptor α signaling prevents protease-mediated embryo death. eLIFE. In press.

Binder AK, Winuthayanon W, Hewitt SC, Couse JF, and Korach, KS. Steroid Receptors in the Ovary and Uterus. In: Plant TM and Zeleznik AJ (eds.), Knobil and Neill’s Physiology of Reproduction, vol. 1, 4th ed. London: Elsevier; 2015: 1099-193.

Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS. (2015) Development of phenotypic and transcriptional biomarkers to establish activity and potency of candidate xenoextrogens. Environ Health Perspect. 123: 334-52.

Winuthayanon W, Hewitt SC, and Korach KS. (2014) Uterine epithelial cell estrogen receptor α –dependent and –independent genomic profiles that underlie estrogen response. Biol Reprod. 95:110, 1-10. *NIEHS paper of the month, 02/15

Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS. (2014) Novel DNA Motif Binding Activity Observed In Vivo With an Estrogen Receptor α Mutant Mouse. Mol Endo. 28: 899-911.

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Arao Y, Burns KA, Hewitt SC, Pedersen LC, and Korach KS. (2013) Natural Estrogenic Compound Diarylheptanoid (D3): In vitro Mechanisms of Action and In Vivo Uterine Responses via Estrogen Receptorα. Environ Health Perspect. 121:433-9.

*NIEHS paper of the month, 06/13

Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, and Korach KS. (2010) Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci USA. 107: 19272-7.

*Post-publication peer reviewed recognition in F1000 as “must read paper”, 11/10
*NIEHS paper of the month, 01/11

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongkol M, Arao Y, Hewitt SC, and Korach KS. (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environ Health Perspect. 117: 1155-61.

Winuthayanon W, Suksen K, Boonchird C, Chuncharunee A, Ponglikitmongkol M, Suksamrarn A, Piyachaturawat P. (2009) Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. requires metabolic activation. J Agric Food Chem. 57: 840-5.

Washington State University