|Department:||Animal Sciences, WSU|
|Credentials:||1986 - Ph.D., University of Zagreb, Croatia; Biotechnology|
|Office:||Animal Science Lab 114|
|Mailing Address:||Department of Animal Sciences|
PO Box 646351
Pullman, WA 99164-6351
Genomics of Reproduction
My research in reproductive genomics includes mapping quantitative trait loci and discovering transcriptome networks that can be used to understand the genetic complexity of reproduction and diseases. We use both candidate gene and genome-wide association study approaches to identify genes or genome regions that are responsible for various complex phenotypes related to ovulation, embryo survival, pregnancy and disease resistance. Transcriptome analysis is based on next-generation sequencing technologies and bioinformatics. Data obtained from these approaches are used to study the gene expression patterns of different reproductive tissues/organs in vertebrates. We focus on systems biology, which enables us to gain insight into possible common regulatory factors and pathways involved in reproduction and diseases.
Miller, L. C., et al. (2014). "Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses." Vet Immunol Immunopathol 159(3-4): 180-191.
Miller LC, Jiang Z, Sang Y, Harhay GP, Lager KM. 2013. "Evolutionary Characterization of Pig Interferon-inducible Transmembrane Gene (IFITMs) Family and Member Expression Dynamics in Tracheal-bronchial Lymph Nodes (TBLN) Infected with Influenza A Virus." Veterinary Immunology and Immunopathology (accepted)
Jiang Z, Zhou X, Michal JJ, Wu XL, Zhang LF, Zhang M, Ding B, Liu B, “Mano” Manoranjan VS, Neill JD, Harhay GP, Kehrli Jr. ME, Miller LC. 2013. "Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus." PLoS ONE (accepted).
Wang H, Xiong K, Sun W, Fu Y, Jiang Z, Yu D, Liu HL, Chen J. 2013. "Two completely linked polymorphisms in the PPARγ transcriptional regulatory region significantly affect gene expression and intramuscular fat deposition in Longissimus Dorsi muscle of Erhualian pigs." Animal Genetics Article first published online: 13 FEB 2013 | DOI: 10.1111/age.12025.
Wei S, Zan L, Wang H, Cheng G, Du M, Jiang Z, Hausman GJ, McFarland DC, Dodson MV. 2013. "FABP4 regulates ADIPOQ, LEP and LEPR expression in bovine preadipocytes." Genetics and Molecular Researchdoi: dx.10.4238/2012.
Zhou X, Michal JJ, Zhang LF, Ding B, Lunney JK, Liu B, Jiang Z. 2013. "Interferon-induced IFIT family in host antiviral defense." International Journal of Biological Sciences 9(2): 200-208.
Zhou X, Jiang T, Du X, Zhou P, Jiang Z, Michal JJ, Liu B. 2013. "Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo." Developmental & Comparative Immunology 39:117-26.
Liu J, Bai J, Lu Q, Zhang L, Jiang Z, Michal JJ, He Q, Jiang P. 2012. "Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine circovirus type 2." Journal of Proteomics 79C:72-86.
Li RS, Sun QW, Jia YM, Cong RH, Ni YD, Yang XJ, Jiang Z, Zhao RQ. 2012. "Coordinated miRNA/mRNA expression profiles for understanding breed-specific metabolic characters of liver between Erhualian and Large White Pigs." PLoS ONE 7: e38716.
Lu Q, Bai J, Zhang LL, Liu J, Jiang Z, Michal JJ, Jiang P. 2012. "Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric Tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus." Journal of Proteome Research 11: 2890–2903.
Zhang LF, Michal JJ, O'Fallon JV, Pan ZX, Gaskins CT, Reeves JJ, Busboom JR, Zhou X, Ding B, Dodson MV, Jiang Z. 2012. "Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F1 progeny". International Journal of Biological Sciences 8: 838-858.
Wei S, Duarte MS, Du M, Paulino PVR, Jiang Z, Albrecht E, Fernyhough-Culver M, Zan L, Dodson MV. 2012. "Bovine mature adipocytes readily return to a proliferative state." Tissue & Cell 44:385-390.
Duarte MS, Wei S, Du M, Jiang Z, Paulino PVR, Zan L, Hausman GJ, Dodson MV. 2012. "Isolation of mature adipocytes and stromal vascular cells under adverse sampling conditions." Journal of Metabolic Syndrome 1(4):112-116.
Wei S, Duarte MS, Du M, Jiang Z, Paulino PVR, Chen J, Fernyhough-Culver ME, Hausman GJ, Zan L, Dodson MV. 2012. "Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro." Adipocyte 1:237-241.
Kunej T, Jevsinek Skok D, Zorc M, Ogrinc A, Michal JJ, Kovac M, Jiang Z. 2012. "Obesity gene atlas in mammals." Journal of Genomics 1: 45-55.
Dodson MV, Wei S, Duarte MS, Du M, Jiang Z, Hausman GJ, Bergen WG. 2012. "Cell supermarket: Adipose tissue as a source of stem cells." Journal of Genomics 1: 39-44.
Wei S, Duarte MS, Zan LS, Du M, Jiang Z, Guan LL, Chen J, Hausman GJ, Dodson MV. 2012. "Cellular and Molecular Implications of Mature Adipocyte Dedifferentiation." Journal of Genomics 1: 5-12.
Godnic I, Calin GA, Horvat S, Jiang Z, Jevsinek Skok D, Zorc M, Dovc P, Kunej T. 2012. "Catalog of microRNA seed polymorphisms in vertebrates." PLoS ONE 7: e30737.
Dodson MV, Jiang Z, Du M, Hausman GJ. 2012. "Adipogenesis: It is not just lipid that comprises adipose tissue." Journal of Genomics 1:1-4.