Participating Faculty

Ram Kasimanickam

Ram Kasimanickam

Diplomate American College of Theriogenology
Phone: 509-335-6060



2002, Doctor in Veterinary Science, Ontario Veterinary College, University of Guelph, Canada 
1991, Bachelor in Veterinary Science, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, 

Research Interests

Improving bull and cow fertility with a population and genomic based approach, embryonic and placental development

Animal models to study intrauterine growth restriction, premature delivery, and postnatal reproductive performances

Research Interests

Reproduction - improving bull and cow fertility with a population based approach, embryonic and placental development. Animal model to study antioxidants and angiogenesis in intrauterine growth retardation, premature delivery.

Research Summary

Angiogenesis is the process of development of new blood vessels. In endothelial cells, hypoxic conditions drive the transcription of multiple genes which control vascular function, expansion and remodeling. Excessive accumulation of free radicals affects placental development and function, and may subsequently impact both the fetus and dam. Dr. Ram Kasimanickam research program in the Department of Veterinary Clinical Sciences aims to investigate the factors that influence placental development through an understanding of angiogenic genes, cytokines, and oxidative stress and therapeutic application of antioxidants and new avenues for the treatment of placental pathology. His lab also investigates role of adipokines in male reproduction, its role in testicular steroidogenesis and sperm DNA functions.

Select Publications
  • Kasimanickam VR, Kasimanickam RK, Dernell WS. (2014) Dysregulated microRNA clusters in response to retinoic acid and CYP26B1 inhibitor induced testicular function in dogs. PLoS One. 9(6):e99433. doi: 10.1371/journal.pone.0099433. eCollection 2014. PMID: 24911586 PMCID: PMC4049822
  • Kasimanickam RK, Firth P, Schuenemann GM, Whitlock BK, Gay JM, Moore DA, Hall JB, Whittier WD. (2014) Effect of the first GnRH and two doses of PGF2alpha in a 5-day progesterone-based CO-Synch protocol on heifer pregnancy. Theriogenology 81(6):797-804. doi: 10.1016/j.theriogenology.2013.12.023. Epub 2014 Jan 4. PMID: 24485555 PMCID:
  • Asokan GV, Kasimanickam RK, Asokan V. (2013) Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health. Infect Ecol Epidemiol 3. doi: 10.3402/iee.v3i0.21386. eCollection 2013. PMID: 24363836 PMCID: PMC3864162
  • Whittier WD, Currin JF, Schramm H, Holland S, Kasimanickam RK. (2013) Fertility in Angus cross beef cows following 5-day CO-Synch + CIDR or 7-day CO-Synch + CIDR estrus synchronization and timed artificial insemination. Theriogenology. 80(9):963-9. doi: 10.1016/j.theriogenology.2013.07.019. Epub 2013 Sep 14. PMID: 24041825 PMCID:
  • Kasimanickam RK, Kasimanickam VR, Olsen JR, Jeffress EJ, Moore DA, Kastelic JP. (2013) Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. Reprod Biol Endocrinol. 11:103. doi: 10.1186/1477-7827-11-103. PMID: 24209779 PMCID: PMC3830449
  • Kasimanickam VR, Kasimanickam RK, Rogers HA. (2013) Immunolocalization of retinoic acid receptor-alpha, -beta, and -gamma, in bovine and canine sperm. Theriogenology 79(6):1010-8. doi: 10.1016/j.theriogenology.2013.01.011. Epub 2013 Mar 7. PMID: 23465288 PMCID:
  • Kasimanickam VR, Kasimanickam RK, Kastelic JP, Stevenson JS. (2013) Associations of adiponectin and fertility estimates in Holstein bulls. Theriogenology 79(5):766-77.e1-3. doi: 10.1016/j.theriogenology.2012.12.001. Epub 2013 Jan 9. PMID: 23312718 PMCID:
  • Kasimanickam VR, Kasimanickam RK. (2013) Expression of CYP26b1 and related retinoic acid signalling molecules in young, peripubertal and adult dog testis Reprod Domest Anim. 48(1):171-6. doi: 10.1111/j.1439-0531.2012.02125.x. Epub 2012 Jun 20. PMID: 22712632 PMCID:
  • Kasimanickam RK, Ranjan A, Asokan GV, Kasimanickam VR, Kastelic JP. (2013) Prevention and treatment of biofilms by hybrid- and nanotechnologies. Int J Nanomedicine. 8:2809-19. doi: 10.2147/IJN.S44100. Epub 2013 Aug 2. PMID: 23946652 PMCID: PMC3739460
  • Kasimanickam VR, Kasimanickam RK. (2013) Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study. Theriogenology 79(1):10-6. doi: 10.1016/j.theriogenology.2012.09.001. Epub 2012 Oct 25. PMID: 23102850 PMCID:

List of Publications