Research Interests

Gamete Biology

Jennifer Watts

Associate Professor; Associate Director, SMB Graduate Program

jwatts@wsu.edu

Office
Room: BLS 433
Phone: 509-335-8554
Lab
Room: BLS 440
Phone: 509-335-8995

Lab Website : http://www.smb.wsu.edu/faculty-trainees-and-staff/faculty/jennifer-watts/lab
 Jennifer Watts

 

 
List of Publications
Select Publications
  • Vrablik TL, Watts JL (2013) Polyunsaturated fatty acid derived signaling in reproduction and development: Insights from Caenorhabditis elegans and Drosophila melanogaster Mol Reprod Dev. 80(4), 244-59 PMID: 23440886 PMCID: PMC4350910 Article
  • Watts JS, Morton DG, Kemphues KJ, Watts JL (2017) The biotin-ligating protein BPL-1 is critical for lipid biosynthesis and polarization of the Caenorhabditis elegans embryo. J Biol Chem pii: jbc.M117.798553. doi: 10.1074/jbc.M117.798553. PMID: 29158261 PMCID: Article
  • Watts JL, Ristow M (2017) Lipid and Carbohydrate Metabolism in Caenorhabditis elegans. Genetics 207(2):413-446. doi: 10.1534/genetics.117.300106. PMID: 28978773 PMCID: PMC5629314 Article
  • Watts JL (2016) Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids. J Clin Med 5(2). pii: E19. doi: 10.3390/jcm5020019. PMID: 26848697 PMCID: PMC4773775 Article
  • Shi X, Tarazona P, Brock TJ, Browse J, Feussner I, Watts JL. (2016) A Caenorhabditis elegans model for ether lipid biosynthesis and function. J Lipid Res 57(2):265-75. doi: 10.1194/jlr.M064808. Epub 2015 Dec 18. PMID: 26685325 PMCID: PMC4727422 Article
  • Deline M, Keller J, Rothe M, Schunck WH, Menzel R, Watts JL (2015) Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans. Sci Rep. 5,15417 PMID: 26486965 PMCID: PMC4614016 Article
  • Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK (2015) s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways. Cell Metab/ 22(4), 633-45 PMID: 26321661 PMCID: PMC4598287 Article
  • Vrablik TL, Petyuk VA, Larson EM, Smith RD, Watts JL (2015) Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein. Biochim Biophys Acta. 1851(10), 1337-45 PMID: 26121959 PMCID: PMC4561591 Article
  • Hou NS, Gutschmidt A, Choi DY, Pather K, Shi X, Watts JL, Hoppe T, Taubert S (2014) Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc Natl Acad Sci U S A. 111(22), E2271-80 PMID: 24843123 PMCID: PMC4050548 Article
  • Deline M, Vrablik TL, Watts JL (2013) Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans. Journal of Visualized Experiments 81 PMID: PMCID: Article
  • Shi X, Li J, Zou X, Greggain J, Rødkær SV, Færgeman NJ, Liang B, Watts JL (2013) Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase. J Lipid Res. 54(9), 2504-14 PMID: 23787165 PMCID: PMC3735947 Article
  • Webster CM, Deline ML, Watts JL (2013) Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans. Dev Biol. 373(1), 14-25 PMID: 23064027 PMCID: PMC3508147 Article
  • Vrablik TL, Watts JL (2012) Emerging roles for specific fatty acids in developmental processes. Genes Dev. 26(7), 631-7 PMID: 22474257 PMCID: PMC3323873 Article
  • Lim MA, Selak MA, Xiang Z, Krainc D, Neve RL, Kraemer BC, Watts JL, Kalb RG (2012) Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. J Neurosci. 32(3)m 1123-41 PMID: 22262909 PMCID: PMC3742882 Article
  • Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM (2011) A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 147(4), 840-52 PMID: 22035958 PMCID: PMC3384509 Article
  • Liang B, Ferguson K, Kadyk L, Watts JL (2010) The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One 5(3) PMID: 20360843 PMCID: PMC2845610 Article
  • Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM (2010) Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 24(13), 1403-17 PMID: 20595232 PMCID: PMC2895199 Article
  • Brooks KK, Liang B, Watts JL (2009) The Influence of Bacterial Diet on Fat Storage in C. elegans PLoS One 4(10) PMID: PMCID: Article
  • Watts JL (2009) Fat Synthesis and Adiposity Regulation in Caenorhabditis elegans Trends in Endocrinology and Metabolism 20, 58-65 PMID: PMCID: Article
  • Brock TJ, Browse J, Watts JL (2007) Fatty Acid Desaturation and the Regulation of Adiposity in Caenorhabditis elegans. Genetics 176, 865-875 PMID: PMCID: Article
  • Schroeder LK, Kremer S, Kramer MJ, Currie E, Kwan E, Watts JL, Lawrenson AL, Hermann GJ (2007) Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle Mol Biol Cell. 18(3), 995-1008 PMID: 17202409 PMCID: PMC1805080 Article
  • Kubagawa HM, Watts JL, Corrigan C, Edmonds JW, Sztul E, Browse J, Miller MA (2006) Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Nat Cell Biol. 8(10), 1143-8 PMID: 16998478 PMCID: Article
  • Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM (2006) An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 442(7103), 700-4 PMID: 16799563 PMCID: Article
  • Brock TJ, Browse J, Watts JL (2006) Genetic Regulation of Unsaturated Fatty Acid Composition in C. elegans PLoS Genet. 2(7) PMID: 16839188 PMCID: PMC1500810 Article
  • Watts JL, Browse J (2006) Dietary manipulation implicates lipid signaling in the maintenance of C. elegans germ cells Dev Biol. 292(2), 381-92 PMID: 16487504 PMCID: PMC1584401 Article