Research Interests

Gamete Biology

Terry Hassold

Professor, SMB Ombudsman

Room: BLS 331
Phone: 509-335-4953 Phone: 509-335-4932

Terry Hassold


Research & Interests

Over 50% of all human pregnancy loss is due to chromosome imbalance in the fetus, making chromosome abnormalities the leading cause of reproductive failure. One of the primary aims of my laboratory is the use of cytogenetic and molecular techniques to study the origin and etiology of human chromosome abnormalities, with the aim being to uncover basic mechanisms responsible for the errors.   Additionally, because of the importance of abnormal meiotic recombination to the genesis of human trisomies, we have recently initiated a series of studies to examine factors responsible for “setting” recombination levels in mammalian males and females.

Select Publications
  • Horan TS, Marre A, Hassold T, Lawson C, Hunt PA. (2017) Germline and reproductive tract effects intensify in male mice with successive generations of exposure. PLoS Genetics 13(7): e1006885 PMID: 28727826 PMCID: PMC5519010 Article
  • Wang S, Hassold T, Hunt P, White MA, Zickler D and Kleckner N (2017) Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis Cell 168(6):977-989.e17 PMID: 28262352 PMCID: PMC5408880 Article
  • Gruhn J, Al-Asmar N, Fasnacht R, Maylor-Hagen H, Peinado V, Rubio C, Broman K, Hunt P, Hassold T (2016) Correlations between synaptic initiation and meiotic recombination: A study of humans and mice. Am J Hum Genet 98, 102-115 PMID: 26749305 PMCID: PMC4716685 Article
  • Vrooman L, Oatley J, Griswold J, Hassold T, Hunt P (2015) Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult. PLoS Genet 11 PMID: 25615633 PMCID: PMC4304829 Article
  • Vrooman LA, Nagaoka SI, Hassold TJ, Hunt PA. (2014) "Evidence for paternal age-related alterations in meiotic chromosome dynamics in the mouse." Genetics. 196(2):385-96. doi: 10.1534/genetics.113.158782. Epub 2013 Dec 6. PMID: 24318536 PMCID: PMC3914612 Article
  • Rowsey R, Gruhn J, Broman K, Hunt P, Hassold T (2014) Examining variation in recombination levels in the human female: a test of the production line hypothesis. Am J Hum Genet 95, 108-112 PMID: 24995869 PMCID: PMC4085639 Article
  • Vrooman L, Nagaoka S, Hassold T, Hunt P (2014) Evidence for paternal-age related alterations in meiotic chromosome dynamics in the mouse.      Genetics 196, 385-396 PMID: 24318536 PMCID: PMC3914612 Article
  • Baier B, Hunt P, Broman K, Hassold T (2014) Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males. PLoS Genet. 10 PMID: 24497841 PMCID: PMC3907295 Article
  • Gruhn J, Rubio C, Broman K, Hunt P, Hassold T (2013) Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS One 8, 85075 PMID: 24376867 PMCID: PMC3869931 Article
  • Rowsey R, Kashevarova A, Murdoch B, Dickenson C, Woodruff T, Cheng E, Hunt P, Hassold T (2013) Germline mosaicism does not explain the maternal age effect on trisomy. Am J Med Genet 161, 2495-2503 PMID: 23950106 PMCID: PMC4012642 Article
  • Gabriel AS, Hassold TJ (2011) Human aneuploidy: mechanisms and insights into an age old problem. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19(2), 155-163 PMID: PMCID: Article
  • Lawson C, Gieske M (2011) Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A. Biology of reproduction 84(1), 79-86 PMID: PMCID: Article
  • Gabriel AS, Hassold TJ (2011) An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype data. Chromosome research 19(2), 155-163 PMID: PMCID: Article
  • Zheng P, Griswold MD, Hassold TJ, Hunt PA, Small CL, Ye P (2010) Predicting Meiotic Pathways in Human Fetal Oogenesis. Biol Reprod. 82(3), 543-51 PMID: 19846598 PMCID: Article
  • Billings T, Sargent EE (2010) Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping PLoS One 5(12) PMID: PMCID: Article
  • Murdoch B, Owen N (2010) Multiple loci contribute to genome-wide recombination levels in male mice. Mammalian genome 21(11-12), 550-555 PMID: PMCID: Article
  • Hunt P, Hassold T (2010) Female meiosis: coming unglued with age. Current biology 20(17), R699-702 PMID: PMCID: Article
  • Hassold T (2010) ASHG Awards and Addresses. 2009 William Allan Award introduction: Huntington F. Willard. American journal of human genetics 86(3), 316-317 PMID: PMCID: Article
  • Houmard B, Small C, Yang L, Naluai-Cecchini T, Cheng E, Hassold T, Griswold MD (2009) Global Gene Expression in the Human Fetal Testis and Ovary. Biol Reprod. 81(2), 438-443 PMID: 19369649 PMCID: Article
  • Hassold T, Hunt P (2009) Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Current opinion in pediatrics 21(6), 703-708 PMID: PMCID: Article
  • Cheng EY, Hent PA (2009) Meiotic recombination in human oocytes. PLoS genetics 5(9) PMID: PMCID: Article
  • Hunt PA, Susiarjo M (2009) The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction. Biology of reproduction 81(5), 807-813 PMID: PMCID: Article
  • Hassold T, Hansen T, Hunt P, VandeVoort C (2009) Cytological studies of recombination in rhesus males. Genome Res. 124(2), 132-8 PMID: PMCID: Article
  • Myers JP, vom Saal FS, Akingbemi BT, Arizono K, Belcher S, Colborn T, Chahoud I, Crain DA, Farabollini F, Guillette Jr LJ, Hassold T, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Laufer H, Marcus M, McLachlan JA, Nadal A, Oehlmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonnenschein C, Soto AM, Talsness CE, Taylor JA, Vandenberg LN, Vandenbergh JG, Vogel S, Watson CS, Welshons WV, Zoeller RT (2009) Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A. Environ Health Perspect 117(3), 309-15 PMID: PMCID: Article
  • Muhlhauser A, Susiarjo M, Rubio C, Griswold J, Gorence G, Hassold T, Hunt PA (2009) Bisphenol A effects on the growing mouse oocyte are influenced by diet. Biol Reprod. 80(5), 1066-71 PMID: PMCID: Article