Research Interests

Reproductive Cancer

Chengtao Her

Associate Professor

Room: BLS 343
Phone: 509-335-7537 Phone: 509-335-7538

Chengtao Her


Research & Interests

My laboratory is interested in the application of the state-of-the-art genomics and proteomics approaches to address fundamental questions related to mammalian DNA mismatch repair pathways. In particular, we are interested in the understanding of the molecular mechanisms underlying mismatch repair genes in human cancer, as well as to study the roles of mismatch repair proteins in homologous recombination and other biological pathways facilitated by the identification and characterization of protein-protein and protein-DNA interactions. All current on-going projects in the laboratory utilize a combination of molecular biology/genomics, protein engineering/proteomics, and gene targeting approaches.

A separate research interest of the laboratory is to develop a green fluorescent protein (GFP)-based protein-protein interaction assay system. Proteins are the ultimate players involved in the vast majority of biological processes and in most cases their functions depend on specific protein-protein interactions. Obviously, one of the central focuses of the emerging field of proteomics is to develop multitasking assay systems for analyzing proteome-wide protein interactions.

List of Publications
Select Publications
  • Xu Y, Her C. (2013) VBP1 facilitates proteasome and autophagy-mediated degradation of MutS homologue hMSH4. FASEB J. 27(12):4799-810. doi: 10.1096/fj.13-235127. Epub 2013 Aug 20. PMID: 23964080 PMCID: PMC3834780 Article
  • Chu YL, Wu X, Xu J, Watts JL, Her C. (2013) DNA damage induced MutS homologue hMSH4 acetylation. Int J Mol Sci. 14(10):20966-82. doi: 10.3390/ijms141020966. PMID: 24145748 PMCID: PMC3821653 Article
  • Wu X, Xu Y, Feng K, Tompkins JD, Her C. (2013) MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants. PLoS One. 8(9):e73284. doi: 10.1371/journal.pone.0073284. eCollection 2013. PMID: 24023853 PMCID: PMC3762724 Article
  • Chu YL, Wu X, Xu Y, Her C. (2013) MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair. Mol Cancer. 12:51. doi: 10.1186/1476-4598-12-51. PMID: 23725059 PMCID: PMC3689047 Article
  • Clark N, Wu X, Her C. (2013) MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases. Curr Genomics. 14(2):81-90. doi: 10.2174/1389202911314020002. PMID: 24082819 PMCID: PMC3637681 Article
  • Zhao N, Zhu F, Yuan F, Haick AK, Fukushige S, Gu L, Her C (2008) The interplay between hMLH1 and hMRE11: role in MMR and the effects of hMLH1 mutations. Biochem Biophys Res Commun. 370(2), 338-43 PMID: 18373977 PMCID: PMC2443822 Article
  • Yang F, Gell K, van der Heijden GW, Eckardt S, Leu NA, Page DC, Benavente R, Her C, Höög C, McLaughlin KJ, Wang PJ (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22(5), 682-91 PMID: 18316482 PMCID: PMC2259036 Article
  • Sekine H, Ferreira RC, Pan-Hammarström Q, Graham RR, Ziemba B, de Vries SS, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott MK, Offer S, Skon C, Du L, Novitzke J, Lee AT, Zhao N, Tompkins JD, Altshuler D, Gregersen PK, Cunningham-Rundles C, Harris RS, Her C, Nelson DL, Hammarström L, Gilkeson GS, Behrens TW (2007) Role for Msh5 in the regulation of Ig class switch recombination. Proc Natl Acad Sci U S A. 104(17), 7193-8 PMID: 17409188 PMCID: PMC1855370 Article
  • Her C, Zhao N, Wu X, Tompkins JD (2007) MutS Homologues hMSH4 and hMSH5: Diverse Functional Implications in Humans. Front Biosci. 12, 905-11 PMID: 17127347 PMCID: Article
  • Lee TH, Yi W, Griswold MD, Zhu F, Her C (2006) Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. DNA Repair (Amst). 5(1), 32-42 PMID: 16122992 PMCID: Article
  • Yi W, Lee TH, Tompkins JD, Zhu F, Wu X, Her C (2006) Physical and functional interaction between hMSH5 and c-Abl. Cancer Res. 66(1), 151-8 PMID: 16397227 PMCID: Article
  • Yi W, Wu X, Lee TH, Doggett NA, Her C (2005) Two variants of MutS homolog hMSH5: Prevalence in humans and effects on protein interaction. Biochem Biophys Res Commun. 332(2), 524-32 PMID: 15907804 PMCID: Article
  • Vo AT, Zhu F, Wu X, Yuan F, Gao Y, Gu L, Li GM, Lee TH, Her C (2005) hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair EMBO Rep. 6(5), 438-44 PMID: 15864295 PMCID: PMC1299302 Article
  • Her C, Wu X, Griswold MD, Zhou F (2003) Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1 (VBP1). Cancer Res. 63(4), 865-72 PMID: 12591739 PMCID: Article
  • Her C, Vo AT, Wu X (2002) Evidence for a direct association of hMRE11 with the Human Mismatch Repair Protein hMLH1 DNA Repair (Amst). 1(9), 719-29 PMID: 12509276 PMCID: Article