Research Interests

Reproductive Cancer


Steven Roberts

Associate Professor

steven.roberts2@wsu.edu

Office
Room: BLS 335
Phone: 509-335-4934
Lab
Room: BLS 340
Phone: 509-335-1421

Steven Roberts

 

 
List of Publications
Select Publications
  • Khodaverdian VY, Hanscom T, Yu AM, Yu TL, Mak V, Brown AJ, Roberts SA, McVey M. (2017) Secondary-structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks.  Nucleic Acids Res 45(22):12848-12861. doi: 10.1093/nar/gkx1056. PMID: 29121353 PMCID: PMC5728401 Article
  • Mao P, Brown AJ, Malc EP, Mieczkowski PA, Smerdon MJ, Roberts SA, Wyrick JJ. (2017) Genome-wide Maps of Alkylation Damage, Repair, and Mutagenesis Reveal Mechanisms of Mutational Heterogeneity Genome Res 27(10):1674-1684. doi: 10.1101/gr.225771.117. Epub 2017 Sep 14. PMID: 28912372 PMCID: PMC5630031 Article
  • Hoopes JI, Hughes AL, Hobson LA, Cortez LM, Brown AJ, Roberts SA. (2017) Avoidance of APOBEC3B-induced mutation by error-free lesion bypass Nucleic Acids Res 45(9):5243-5254. doi: 10.1093/nar/gkx169. PMID: 28334887 PMCID: PMC5605239 Article
  • Saini N, Roberts SA, Sterling JF, Malc EP, Mieczkowski PA, Gordenin DA. (2017) APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast DNA Repair (Amst) 53:4-14. doi: 10.1016/j.dnarep.2017.03.003. Epub 2017 Mar 21. PMID: 28351647 PMCID: PMC5450012 Article
  • Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. (2016) The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS Genet. 12(10):e1006385. doi: 10.1371/journal.pgen.1006385. eCollection 2016 Oct. PMID: 27788131 PMCID: PMC5082821 Article
  • Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA. (2016) Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks. Mol Cell. 63(4):662-673. doi: 10.1016/j.molcel.2016.06.020. Epub 2016 Jul 21. PMID: 27453047 PMCID: PMC4992412 Article
  • Hoopes JI, Cortez LM, Mertz TM, Malc EP, Mieczkowski PA, Roberts SA. (2016) APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.  Cell Rep 14(6):1273-1282. doi: 10.1016/j.celrep.2016.01.021. Epub 2016 Jan 28. PMID: 26832400 PMCID: PMC4758883 Article
  • Mao P, Smerdon MJ, Roberts SA, Wyrick JJ (2016) Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution. Pro Natl Acad Sci USE. 113(32), 9057-62 PMID: 27457959 PMCID: PMC4987812 Article
  • Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. (2014) Break-induced replication is a source of mutation clusters underlying kataegis. Cell Rep. 7(5), 1640-8 PMID: 24882007 PMCID: PMC4274036 Article
  • Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA (2014) Requirements for 5'dRP/AP lyase activity in Ku. Nucleic Acids Res. 42(17), 11136-43 PMID: 25200085 PMCID: PMC4176175 Article
  • The Cancer Genome Atlas Research Network (2014) The somatic genomic landscape of chromophobe renal cell carcinoma Cancer Cell. PMID: PMCID: Article
  • Cancer Genome Atlas Research Network. (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 507(7492), 315-22 PMID: 24476821 PMCID: PMC3962515 Article
  • Roberts SA, Gordenin, Dmitry A (2014) Clustered Mutations in Human Cancer. eLS. John Wiley & Sons Ltd, Chichester. PMID: PMCID: Article
  • Roberts SA, Gordenin DA (2014) Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness. Bioessays. PMID: 24615916 PMCID: PMC4145046 Article
  • Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, Kiezun A, Kryukov GV, Carter SL, Saksena G, Harris S, Shah RR, Resnick MA, Getz G, Gordenin DA. (2013) An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 45(9), 970-6 PMID: 23852170 PMCID: PMC3789062 Article
  • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CW, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G (2013) Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 499(7457), 214-8 PMID: 23770567 PMCID: PMC3919509 Article
  • Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA (2012) Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions. Mol Cell. 46(4), 424-35 PMID: 22607975 PMCID: PMC3361558 Article
  • Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA (2012) Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS Genet. 8(12) PMID: 23271983 PMCID: PMC3521656 Article
  • Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA (2012) Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends. J Biol Chem. 287(17), 13686-93 PMID: 22362780 PMCID: PMC3340204 Article
  • Burch LH, Yang Y, Sterling JF, Roberts SA, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA (2011) Damage-induced localized hypermutability. Cell Cycle. 10(7), 1073-85 PMID: 21406975 PMCID: PMC3100884 Article
  • Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 464(7292), 1214-7 PMID: 20383123 PMCID: PMC2859099 Article
  • Roberts SA, Ramsden DA (2007) Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends. J Biol Chem. 282(14), 10605-13 PMID: 17289670 PMCID: Article